Muhammad S. Shahid, Ikram A. Burney


Cancer is a complex disease and is the leading cause of mortality that affects millions of people across the globe. Cancer is challenging to treat, and current treatments including surgery, radiotherapy and systemic treatments have improved significantly over time; however, a better and effective treatment of cancer remains a challenge for patients, wellness professionals, investigators and scientists. Therefore, it is necessary to develop targeted and less toxic therapies for cancer. Recent research has revealed that plant viruses, occurring naturally, can invade a host cell for their replication and reproduction, and thus may have the ability to use as a tool to treat cancer. Plant viruses, occurring naturally, possess a remarkable ability to infiltrate host cells for their replication and propagation. This unique characteristic positions them as potential tools in the fight against cancer. Unlike conventional therapies, plant viruses are harmless to humans and can be engineered to specifically target cancer cells. Furthermore, the size and genome organization of different proteins of plant viruses are very small in diameter, making them an ideal size for transmission in the blood flow and have potential for carrying and discharge of payload to target cancer cells. This inherent capability holds immense potential for developing targeted and less toxic therapies for cancer, offering hope for improved outcomes and quality of life for cancer patients.


Plant viruses, nanoparticles, cancer immunotherapy, drug delivery

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Basuki, J. S., H. T. T. Duong, L. R. MacKenzie and J. A. Goding. 2017. Potato virus X as a novel platform for potential biomedical applications. Biotechnology Advances, 35(1): 83-93.

Bruckman, M. A., A. E. Czapar and N. F. Steinmetz. 2018. Drug-loaded plant-virus based (Nps) for cancer drug delivery. Virus-Derived (Nps) for Advanced Technologies: Methods and Protocols, 425-436.

Czapar, A.E., Y. R. Zheng, I.A. Riddell, S. Shukla, S.G., Awuah, S.J., Lippard N. F. and Steinmetz. 2016. Tobacco mosaic virus delivery of phenanthriplatin for cancer therapy. ACS Nano, 10: 4119–4126.

Ferlay, J., M. Colombet, I. Soerjomataram, R. Siegel, L. Torre and A. Jemal. 2018. Global and regional estimates of the incidence and mortality for 38 cancers: GLOBOCAN. World Health Organization, International Agency for Research on Cancer: Lyon, France. 2018:14.

Global health estimates: Leading causes of death (

Human Development Report. 2019. Human Development Reports (

Koprowski, H. and V. Yusibov. 2001. The green revolution: plants as heterologous expression vectors. Vaccine, 19(17-19): 2735-2741.

Lan, T., Y. Wang, C. Zhang, X. Zhang, Y. Wu and Z. Zhong. 2020. Multifunctional sesbania mosaic virus-like particles for gene delivery and magnetic resonance imaging. Nanoscale, 12(22): 12111-12119.

Lee, K. L. 2017. Plant virus-based (Nps) as a vaccine and gene delivery platform. Nano Today, 17: 23-37.

Liu, H. 2020. Tumor-specific immune response induced by a tobacco mosaic virus-based cancer vaccine. ACS Applied Materials & Interfaces, 12(16): 18356-18363.

Lizotte, P.H., A.M. Wen and M. R. Sheen. 2016. In situ vaccination with Cowpea mosaic virus (Nps) suppresses metastatic cancer. Natural Nanotechnology, 11(3): 295-303.

Miermont, A., H. Barnhill and E. Strable. 2008. Cowpea mosaic virus capsid: a promising carrier for the development of carbohydrate based antitumor vaccines. Chemistry, 14(16): 4939-4947.

Nkanga, C. I. and N. F. Steinmetz. 2021. The pharmacology of plant virus (Nps). Virology, 556: 39-61.

Ren, Y., S. M. Wong and L. Y. Lim. 2007. Folic acid-conjugated protein cages of a plant virus: a novel delivery platform for doxorubicin. Bioconjugation Chemistry, 18(3): 836-843.

Ren, Y., S. M. Wong and L. Y. Lim. 2010. Application of plant viruses as nano drug-delivery systems. Pharmaceutical Research, 27(11): 2509–2513.

Narayanan, K. B. and S. S. Han. 2018. Recombinant helical plant virus-based nanoparticles for vaccination and immunotherapy. Virus Genes, 54(5): 623-637.

Sung, H., J. Ferlay, R. L. Siegel, M. Laversanne, I. Soerjomataram, A. Jemal and F. Bray. 2021. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 71(3): 209-249.

Yusibov, V., S.J. Streatfield and N. Kushnir. 2015. Clinical development of plant-produced recombinant pharmaceuticals: vaccines, antibodies and beyond. Hum Vaccine Immunotherapy, 11(6):1361-1371.

Zhang, X., R. Rastogi and Y. Wu. 2019. Cowpea mosaic virus-based cancer therapy. Bioconjugate Chemistry, 30(4): 940-951.



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Pakistan Journal of Phytopathology
ISSN: 1019-763X (Print), 2305-0284 (Online).
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